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KMID : 1001020170150020059
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Journal of Urologic Oncology
2017 Volume.15 No. 2 p.59 ~ p.65
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Clinical Outcomes of Continuous Addition of Androgen Deprivation Therapy During Docetaxel Chemotherapy for Patients With Castration-Resistant Prostate Cancer
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Lee Dong-Hoon
Kim Jung-Ho
Seo Won-Ik
Nam Jong-Kil
Kim Tae-Nam
Oh Cheol-Kyu
Kim Soo-Dong
Park Sung-Woo
Chung Jae-Sung
Park Sang-Hyun
Lee Wan
Sung Gyung-Tak
Chung Moon-Kee
Chung Jae-Il
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Abstract
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Purpose: This study compared the oncologic results of docetaxel chemotherapy (DOC) in castration-resistant prostate cancer (CRPC) according to continuous addition of androgen deprivation therapy (ADT) during chemotherapy.
Materials and Methods: We retrospectively reviewed the medical records of 106 patients who received DOC in 6 medical institutes. Among them, 72 patients had a complete medical record: 28 patients with ADT (DOC+continuous ADT group) and 44 without ADT (DOC only group). We compared the progression-free survival of these groups after DOC.
Results: Docetaxel was administered an average of 28 months after primary ADT as the first treatment. A median number of 6 cycles of DOC was administered in both groups. In the DOC+continuous ADT group, orchiectomy was performed in 18 patients and luteinizing hormone-releasing hormone agonist was injected in 10 patients. During DOC treatment, prostate-specific antigen (PSA) progression-free survival was statistically different (6.0±4.75 months in DOC+continuous ADT group vs. 4.8±3.2 months in DOC only group, p=0.024), whereas radiologic progression-free survival was not statistically different (5.0±3.12 months in DOC+continuous ADT group vs. 5.0±2.79 months in DOC only group, p=0.387).
Conclusions: In our cohort, continuous addition of ADT showed a significant benefit in PSA progression-free survival during DOC in CRPC patients. Further prospective studies are needed to confirm these observations.
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KEYWORD
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Androgen deprivation therapy, Castration-resistant prostate cancer, Docetaxel chemotherapy
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